Important things to know when starting Lyumjev
Watch this video on how to inject your Lyumjev KwikPen® and read the instructions for use.
Everyone’s experience with a medicine can be different. It’s important to know possible side effects to look for.
How should I take Lyumjev?
Lyumjev is a fast-acting insulin used to treat adults with diabetes for the control of high blood sugar
Take Lyumjev with your first bite
Lyumjev starts working fast. Take it at the start of your meal or within 20 minutes after you start eating to reduce your blood sugar.
Lyumjev can be taken with a prefilled KwikPen or from a vial with a syringe, just like Humalog® (insulin lispro injection, 100 units/mL). The steps to inject Lyumjev are also the same as for Humalog.
Be sure to take your insulin and check your blood sugar levels exactly as your doctor tells you to. Your doctor may tell you to change your dose because of illness, increased stress, or changes in your weight, diet, or physical activity level. He or she may also tell you to change the amount or time of your dose because of other medicines or different types of insulin you take.
Select Safety Information
Lyumjev may cause serious side effects. Some of these can lead to death. The possible serious side effects are:
- Low blood sugar. This can cause:
- dizziness or lightheadedness
- blurred vision
- fast heartbeat
- mood change
- slurred speech
If you are at risk of having severely low blood sugar, your doctor may prescribe a glucagon emergency kit. These are used when your blood sugar becomes too low and you are unable to take sugar by mouth. Glucagon helps your body release sugar into your bloodstream.
The most common side effects of Lyumjev are:
- Low blood sugar
- Allergic reactions
- Reactions where you have injected insulin
- Thickening or pits at the injection site
- Weight gain
In clinical studies, up to 3% of people taking Lyumjev experienced injection site reactions.* These reactions were usually mild.
When taking Lyumjev, it’s important to remember:
- Change (rotate) where you inject your insulin with each dose. This can reduce your chance of getting pits, lumps, or thickened skin where you inject your insulin
- Do not inject your insulin into the exact same spot or where the skin has pits or lumps
- Avoid injecting into thickened, tender, bruised, scaly, hard, scarred, or damaged skin
These are not all of the possible side effects. Tell your doctor if you have any side effects. You can report side effects at 1‑800‑FDA‑1088 or www.fda.gov/medwatch.
How to take Lyumjev
Watch our How to Use Video to learn how to take Lyumjev with your KwikPen.
You can also view the written instructions below and follow the links to the full Instructions for Use. Please be sure to review all instructions before you start using Lyumjev and each time you refill.
How to Inject Using the Lyumjev KwikPen
Please read the step-by-step instructions that come with your device for more complete directions.
Prepare your Pen
- Make sure you have the right insulin
- Pull the Pen cap off. Wipe the rubber seal with alcohol
- Remove the paper tab from the Pen needle
- Put a new needle onto the Pen and twist it until it is tight
- Pull off the outer shield. Do not throw it away
- Pull off the inner shield. Throw it away
Select your dose
- Turn the dose knob until the number of units you need to inject appears in the window
Give your injection
- Pick a spot to inject—belly, upper legs, upper arms, or buttocks. Choose a different spot each time you inject to reduce your risk of getting lipodystrophy (pits in skin or thickened skin) and localized cutaneous amyloidosis (skin with lumps) at the injection sites.
- Wipe your skin with alcohol and let it dry
- When you’re ready, put the needle straight in, then push the dose knob until it stops. Count to “5” slowly
- Pull the needle out of your skin
- Make sure there is a “0” in the window
- Put the outer needle shield back on the needle
- Unscrew the used needle from the Pen and put it in a sharps container
- Recap the Pen. Store your Pen at room temperature (up to 86 °F or 30 °C)
- In-use Pen: Throw away the Pen you are using after 28 days, even if it still has insulin left in it
Other ways to take Lyumjev
There is another way to take Lyumjev besides using the Lyumjev KwikPen. Lyumjev U-100 is also available in a vial and can be given with a U-100 insulin syringe.
If your doctor has prescribed Lyumjev U-200 for you, click here to learn how to use the Lyumjev U-200 KwikPen.