How to Take Lyumjev
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Watch our How to Use Video to learn how to take Lyumjev with your KwikPen.
You can also view the written instructions below and follow the links to the full Instructions for Use. Please be sure to review all instructions before you start using Lyumjev and each time you refill.
Do not take Lyumjev if you have:
- symptoms of low blood sugar (hypoglycemia)
- an allergy to insulin lispro-aabc or any of the ingredients in Lyumjev.
How to Inject Using the Lyumjev KwikPen
Please read the step-by-step instructions that come with your device for more complete directions.
Prepare your Pen
- Make sure you have the right insulin
- Pull the Pen cap off. Wipe the rubber seal with alcohol
- Remove the paper tab from the Pen needle
- Put a new needle onto the Pen and twist it until it is tight
- Pull off the outer shield. Do not throw it away
- Pull off the inner shield. Throw it away
Prime your Pen
- Turn the dose knob to 2 units
- Hold the Pen with the needle pointing up and tap gently
- Then push the dose knob until it stops and you see “0” in the dose window
- Count to “5” slowly. You should see insulin at the tip of the needle. If you do not see insulin, repeat the priming steps, but no more than 4 times
Select your dose
- Turn the dose knob until the number of units you need to inject appears in the window
Give your injection
- Pick a spot to inject—belly, upper legs, upper arms, or buttocks. Choose a different spot each time you inject to reduce your risk of getting lipodystrophy (pits in skin or thickened skin) and localized cutaneous amyloidosis (skin with lumps) at the injection sites.
- Wipe your skin with alcohol and let it dry
- When you’re ready, put the needle straight in, then push the dose knob until it stops. Count to “5” slowly
- Pull the needle out of your skin
- Make sure there is a “0” in the window
- Put the outer needle shield back on the needle
- Unscrew the used needle from the Pen and put it in a sharps container
- Recap the Pen. Store your Pen at room temperature (up to 86 °F or 30 °C)
- In-use Pen: Throw away the Pen you are using after 28 days, even if it still has insulin left in it
See links below for more information on:
Do not reuse needles or share your insulin injection supplies with other people. This includes your:
- prefilled pen for use by a single patient
- cartridges
- needles
- syringes
You or the other person can get a serious infection. This can happen even if you change the needle.
How to administer Lyumjev U-100 using an insulin pump
Lyumjev is a fast-acting insulin used to treat adults with diabetes for the control of high blood sugar.
Read the full Instructions for Use that came with your Lyumjev for more information.
Important considerations when taking Lyumjev U-100 in a pump:
- Use your pump and insulin exactly as your doctor tells you to and according to the user manual. Check your pump’s instructions to make sure it can be used with Lyumjev U-100.
- Change the Lyumjev in your pump reservoir according to the pump’s instructions even if you haven’t used all the insulin. Throw insulin away if exposed to temperatures higher than 98.6 °F (37 °C).
- Change infusion sets and choose your infusion site according to your pump’s instructions. Rotate sites to reduce your chance of getting pits, lumps, or thickened skin and don’t place your set into thickened, tender, bruised, scaly, hard, scarred, or damaged skin. Change your site and tell your doctor if the skin around your site becomes red, itchy, pitted, lumpy, or thickened.
- Pump malfunctions, infusion site issues, or insulin that is no longer effective can cause high blood sugar and ketoacidosis (buildup of ketones in the body). Pump malfunctions can also cause low blood sugar. Talk to your doctor about when to switch to insulin injections if these issues can’t be resolved quickly.
- Do not use Lyumjev U-200 in an insulin pump. Do not mix Lyumjev with other insulins or liquids.
If you have additional questions, give us a call at 1-800-LillyRx ( 1-800-545-5979 ).
Do not change the type of insulin you take or your dose, unless your doctor tells you to. This could cause low or high blood sugar, which could be serious. Do not inject your insulin into the exact same spot or where the skin has pits or lumps. Avoid injecting into thickened, tender, bruised, scaly, hard, scarred, or damaged skin.
Lyumjev may cause serious side effects. Some of these can lead to death. The possible serious side effects are:
- Sudden onset of high blood sugar and high amounts of ketones in your blood or urine. You can have these serious side effects when your insulin pump or infusion set is not working the right way, or if there are handling errors. For these reasons, you may not get the right amount of insulin, so always keep extra insulin and injection supplies with you.
If you use insulin in a pump, talk to your healthcare provider about infusion sites, including:
Skin barriers or other treatments to prevent symptoms or offer relief if you experience infusion site reactions. With any insulin therapy, you may experience rash, redness, inflammation, pain, bruising, or itching at the infusion site
Whether you should consider changing your cannula length and/or type if you experience infusion site reactions.
Rotating infusion sites to reduce your risk of getting pits, lumps, or thickened skin
Avoiding sites where the skin is tender or injured, or that may experience muscle movement or trauma
If you notice any irritation around your infusion site, tell your doctor.
Check your blood sugar levels regularly, especially when changing infusion sites. Ask your doctor what your blood sugar levels should be and when you should check your blood sugar.
Always follow your insulin pump's instructions, as well as the instructions that come with your insulin, for specific information about using it in a pump. Always use your insulin and pump exactly as your doctor tells you to.
Do not use a syringe to remove Lyumjev from your prefilled pen. This can cause you to take too much insulin. Taking too much insulin can lead to severe low blood sugar. This may result in seizures or death.
Important Facts About LYUMJEV® (LOOM-jehv) and Humalog® (HU-ma-log)
- Lyumjev is also known as insulin lispro-aabc injection. Humalog is also known as insulin lispro injection.
- Lyumjev is a fast-acting insulin. Lyumjev is used to control high blood sugar in adults with diabetes. Humalog is a fast-acting insulin. Humalog is used to control high blood sugar in adults and children with diabetes. Lyumjev and Humalog are available only with a prescription.
- Lyumjev comes in two strengths: U-100 (100 units per milliliter) and U-200 (200 units per milliliter). Lyumjev U-200 contains 2 times as much insulin in 1 milliliter as Lyumjev U-100. Humalog U-100 contains 100 units of insulin per milliliter. The dose window of the pen shows the number of insulin units to be delivered.
- It is not known if Lyumjev is safe and effective for children. It is not known if Humalog is safe and effective for children with type 2 diabetes or for children younger than 3 years of age with type 1 diabetes as there were no studies done with Humalog in these groups of children. If your doctor decides to give your child any insulin products, he or she may give you special instructions.
All Lyumjev and Humalog products contain insulin lispro.
Warnings
Do not take Lyumjev or Humalog if you have:
- symptoms of low blood sugar (hypoglycemia)
- an allergy to insulin lispro-aabc, Humalog, or any of the ingredients in Lyumjev or Humalog.
Do not reuse needles or share your insulin injection supplies with other people. This includes your:
- prefilled pen for use by a single patient
- cartridges
- reusable pen that works with Lilly 3mL cartridges available for Humalog
- needles
- syringes
You or the other person can get a serious infection. This can happen even if you change the needle.
Do not change the type of insulin you take or your dose, unless your doctor tells you to. This could cause low or high blood sugar, which could be serious.
Do not use a syringe to remove Lyumjev or Humalog from your prefilled pen. This can cause you to take too much insulin. Taking too much insulin can lead to severe low blood sugar. This may result in seizures or death.
Lyumjev and Humalog may cause serious side effects. Some of these can lead to death. The possible serious side effects are:
- Low blood sugar. This can cause:
- dizziness or lightheadedness
- headache
- shakiness
- irritability
- sweating
- blurred vision
- fast heartbeat
- mood change
- confusion
- slurred speech
- anxiety
- hunger
If you are at risk of having severely low blood sugar, your doctor may prescribe a glucagon emergency kit. These are used when your blood sugar becomes too low and you are unable to take sugar by mouth. Glucagon helps your body release sugar into your bloodstream.
- Low potassium in your blood. This can lead to severe breathing problems, irregular heartbeat, and death.
- Severe allergic reaction.
Get emergency help right away if you have:
- a rash over your whole body
- sweating
- extreme drowsiness
- swelling of your face, tongue, or throat
- trouble breathing
- a faint feeling
- dizziness
- a fast heartbeat
- shortness of breath
- confusion
- Heart failure. Taking diabetes pills called thiazolidinediones (thIE-uh-zOH-li-dEEn-dIE-OHns), or "TZDs," with Lyumjev or Humalog may cause heart failure in some people. This includes people who do not have any heart problems. If you have heart failure, it may get worse if you take TZDs with Lyumjev or Humalog. Tell your doctor if you have any new symptoms of heart failure, or if they get worse. Some symptoms of heart failure include: shortness of breath, swelling of ankles and feet, and sudden weight gain. Your doctor may need to change or stop treatment with TZDs and your insulin lispro product.
- Sudden onset of high blood sugar and high amounts of ketones in your blood or urine. You can have these serious side effects when your insulin pump or infusion set is not working the right way, if there are handling errors, or if your insulin is no longer effective. For these reasons, you may not get the right amount of insulin, so always keep extra insulin and injection supplies with you.
Common side effects
The most common side effects of Lyumjev and Humalog are:
- low blood sugar
- reactions or pain at the injection or infusion site with insulin pump use
- itching
- weight gain
- allergic reactions
- skin thickening or pits at the injection or infusion site
- rash
Other most common side effects with Humalog include swelling of your hands or feet.
These are not all of the possible side effects. Tell your doctor if you have any side effects. You can report side effects at 1‑800‑FDA‑1088 or www.fda.gov/medwatch .
Before using
Talk with your doctor about low blood sugar and how to manage it. Also tell your doctor:
- about all of the medicines you take, including over-the-counter medicines, vitamins, and herbal supplements.
- about any other prescription medicines you take, especially ones called TZDs.
- about all of your medical conditions, including if you have heart failure or other heart, liver, or kidney problems.
- if you are pregnant, breastfeeding, or plan to become pregnant or breastfeed.
How to take
Read the Instructions for Use that come with your Lyumjev or Humalog. Be sure to take your Lyumjev or Humalog and check your blood sugar levels exactly as your doctor tells you to. Your doctor may tell you to change your dose because of illness, increased stress, or changes in your weight, diet, or physical activity level. He or she may also tell you to change the amount or time of your dose because of other medicines or different types of insulin you take.
Before injecting your Lyumjev or Humalog
You can inject your insulin dose yourself, or you can have a trained caregiver inject it for you. Make sure you or your caregiver:
- Check the insulin label before each injection. This will help you make sure that you are taking the correct insulin.
- Use a new needle for each injection. You can get a serious infection or the wrong dose of insulin if you reuse needles.
- Change (rotate) where you inject your insulin with each dose. This can reduce your chance of getting pits, lumps, or thickened skin where you inject your insulin. Do not inject your insulin into the exact same spot or where the skin has pits or lumps. Avoid injecting into thickened, tender, bruised, scaly, hard, scarred, or damaged skin.
When you are ready to inject
- Inject Lyumjev under your skin at the beginning of a meal or within 20 minutes after you start eating a meal.
- Inject Humalog under your skin within 15 minutes before or right after you eat a meal.
Staying safe while taking your Lyumjev or Humalog
To stay safe while taking your insulin, be sure to never inject Lyumjev U-200 in your vein, muscle, or with an insulin pump. Also be sure not to:
- mix Lyumjev with other insulins or liquids
- drive or use heavy machinery until you know how your Lyumjev or Humalog affects you.
- drink alcohol or use other medicines that contain alcohol when taking your Lyumjev or Humalog.
Learn more
For more information, call 1-800-545-5979 or go to www.Lyumjev.com or www.humalog.com
This summary provides basic information about Lyumjev and Humalog. It does not include all information known about these medicines. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other healthcare provider about your insulin lispro product and how to take it. Your doctor is the best person to help you decide if these medicines are right for you.
Lyumjev® and Humalog® are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.
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