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Welcome to Lyumjev

Where would you like to start?

Learn About Lyumjev
Getting Started
How to Take Lyumjev

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Welcome to Lyumjev

Where would you like to start?

Learn About Lyumjev
Getting Started
How to Take Lyumjev

Lyumjev is a fast-acting insulin used to treat adults and children with diabetes for the control of high blood sugar

Lyumjev (pronounced LOOM-jehv )

In adults with diabetes, Lyumjev,

Helps to provide proven A1C reduction in Type 1 and Type 2 diabetes ^1-3
Is designed to reduce blood sugar spikes that happen naturally after a meal
Controls after meal blood sugar, similar to how natural insulin works after meals in people without diabetes

In children with diabetes, Lyumjev helps control high blood sugar

Lyumjev can be given with a KwikPen^®, insulin pump, or a vial and syringe. Lyumjev is also available in a Tempo Pen^™.

Lyumjev U-200 cannot be given by an insulin pump.
Check your insulin pump’s user manual to see if it can be used with Lyumjev U-100. Follow the instructions in your pump’s user guide when taking Lyumjev.

Explore Lyumjev

Select Safety Information

Do not take Lyumjev if you have :

symptoms of low blood sugar (hypoglycemia)
an allergy to insulin lispro-aabc or any of the ingredients in Lyumjev.

Your medicine is now available for home delivery!

LillyDirect^™ is a new option to connect you to resources, including home delivery of your medicine via LillyDirect powered by Truepill^®.

Learn about LillyDirect

Lyumjev patient experiences

"Now that I dose with Lyumjev at the start of the meal, I have been able to improve glycemic control and decrease after-meal glucose spikes."

-Ken, Lyumjev Patient & Dexcom Warrior

Talk to your doctor to see if Lyumjev is right for you.

Share Your Lyumjev Story

If you have had a positive experience on Lyumjev, help other patients by sharing your story.

Give us a call at 1-800-LillyRx ( 1-800-545-5979 ) to share your experience on Lyumjev.

Pay as little as $25*

If you have a commercial drug insurance plan with coverage for Lyumjev, you may be eligible to pay as little as $25 for your prescription.^* Download your activated Lyumjev Savings Card today.

Government beneficiaries excluded; terms and conditions apply.

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Terms and Conditions

^*Offer good for up to 12 months. Patients must have coverage for Lyumjev through their commercial drug insurance coverage to pay as little as $25 for a 30-day supply of Lyumjev. Offer subject to a monthly cap of $100 and a separate annual cap of $1200. Offer void where prohibited by law. Patient is responsible for any applicable taxes, fees, or amounts exceeding monthly or annual caps. This offer is invalid for Patients without commercial drug insurance or whose prescription claims for Lyumjev are eligible to be reimbursed, in whole or in part, by any governmental program, including, without limitation, Medicaid, Medicare, Medicare Part D, Medigap, DoD, VA, TRICARE^®/CHAMPUS, or any State Patient or Pharmaceutical Assistance Program. Offer void where prohibited by law and subject to change or discontinue without notice. Card activation is required. Subject to additional terms and conditions .

Already have a Lyumjev Savings Card?

Activate your card now and start saving on your Lyumjev prescription.

Do not reuse needles or share your insulin injection supplies with other people. This includes your:

prefilled pen for use by a single patient
cartridges
needles
syringes

You or the other person can get a serious infection. This can happen even if you change the needle.

Already taking a mealtime insulin?

Learn about changing to Lyumjev

References

Lyumjev. Prescribing Information. Lilly USA, LLC.
Klaff LJ, Cao D, Dellva MA, et al. Ultra rapid lispro (URLi) improves postprandial glucose (PPG) control vs. Humalog (lispro) in T1D: PRONTO-T1D Study. Diabetes. 2019;68(suppl 1). doi:10.2337/db19-144-OR.
Blevins T, Zhang Q, Frias JP, Jinnouchi H, Chang AM. Ultra rapid lispro (URLi) improves postprandial glucose (PPG) control vs. Humalog (lispro) in patients with type 2 diabetes (T2D): PRONTO-T2D. Diabetes. 2019;68(suppl 1). doi:10.2337/db19-145-OR.

SAFETY SUMMARY

Warnings -

Do not take Lyumjev or Humalog if you have:

symptoms of low blood sugar (hypoglycemia)
an allergy to insulin lispro-aabc, Humalog, or any of the ingredients in Lyumjev or Humalog.

Do not reuse needles or share your insulin injection supplies with other people. This includes your:

prefilled pen for use by a single patient
cartridges
reusable pen that works with Lilly 3mL cartridges available for Humalog
needles
syringes

You or the other person can get a serious infection. This can happen even if you change the needle.

Do not change the type of insulin you take or your dose unless your doctor tells you to. This could cause low or high blood sugar, which could be serious.
Do not use a syringe to remove Lyumjev or Humalog from your prefilled pen. This can cause you to take too much insulin. Taking too much insulin can lead to severe low blood sugar. This may result in seizures or death.
Lyumjev and Humalog may cause serious side effects. Some of these can lead to death. The possible serious side effects are:

Low blood sugar. This can cause:
- dizziness or lightheadedness
- headache
- shakiness
- irritability
- sweating
- blurred vision
- fast heartbeat
- mood change
- confusion
- slurred speech
- anxiety
- hunger
If you are at risk of having severely low blood sugar, your doctor may prescribe a glucagon emergency kit. These are used when your blood sugar becomes too low and you are unable to take sugar by mouth. Glucagon helps your body release sugar into your bloodstream.
Low potassium in your blood. This can lead to severe breathing problems, irregular heartbeat, and death.
Severe allergic reaction.
Get emergency help right away if you have:
- a rash over your whole body
- sweating
- extreme drowsiness
- swelling of your face, tongue, or throat
- trouble breathing
- a faint feeling
- dizziness
- a fast heartbeat
- shortness of breath
- confusion
Heart failure. Taking diabetes pills called thiazolidinediones (thIE-uh-zOH-li-dEEn-dIE-OHns), or “TZDs,” with Lyumjev or Humalog may cause heart failure in some people. This includes people who do not have any heart problems. If you have heart failure, it may get worse if you take TZDs with Lyumjev or Humalog. Tell your doctor if you have any new symptoms of heart failure, or if they get worse. Some symptoms of heart failure include shortness of breath, swelling of ankles and feet, and sudden weight gain. Your doctor may need to change or stop treatment with TZDs and your insulin lispro product.
Sudden onset of high blood sugar and high amounts of ketones in your blood or urine. You can have these serious side effects when your insulin pump or infusion set is not working the right way, if there are handling errors, or if your insulin is no longer effective. For these reasons, you may not get the right amount of insulin, so always keep extra insulin and injection supplies with you.

Common side effects

The most common side effects of Lyumjev and Humalog are:

low blood sugar
reactions or pain at the injection or infusion site with insulin pump use
itching
weight gain

allergic reactions
skin thickening or pits at the injection or infusion site
rash

Other most common side effects with Humalog include swelling of your hands or feet.

These are not all of the possible side effects. Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch .

Before using

Talk with your doctor about low blood sugar and how to manage it. Also tell your doctor:

about all of the medicines you take, including over-the-counter medicines, vitamins, and herbal supplements.
about any other prescription medicines you take, especially ones called TZDs.
about all of your medical conditions, including if you have heart failure or other heart, liver, or kidney problems.
if you are pregnant, breastfeeding, or plan to become pregnant or breastfeed.

How to take

Read the Instructions for Use that come with your Lyumjev or Humalog. Be sure to take your Lyumjev or Humalog and check your blood sugar levels exactly as your doctor tells you to. Your doctor may tell you to change your dose because of illness, increased stress, or changes in your weight, diet, or physical activity level. He or she may also tell you to change the amount or time of your dose because of other medicines or different types of insulin you take.

Before injecting your Lyumjev or Humalog
You can inject your insulin dose yourself, or you can have a trained caregiver inject it for you. Make sure you or your caregiver:

Check the insulin label before each injection. This will help you make sure that you are taking the correct insulin.
Use a new needle for each injection. You can get a serious infection or the wrong dose of insulin if you reuse needles.
Change (rotate) where you inject your insulin with each dose. This can reduce your chance of getting pits, lumps, or thickened skin where you inject your insulin. Do not inject your insulin into the exact same spot or where the skin has pits or lumps. Avoid injecting into thickened, tender, bruised, scaly, hard, scarred, or damaged skin.
Monitor injection and infusion sites closely when initiating therapy with Lyumjev in children. Contact a healthcare provider if persistent injection or infusion site reactions occur.

When you are ready to inject

Inject Lyumjev under your skin at the beginning of a meal or within 20 minutes after you start eating a meal.
Inject Humalog under your skin within 15 minutes before or right after you eat a meal.

Staying safe while taking your Lyumjev or Humalog
To stay safe while taking your insulin, be sure to never inject Lyumjev U-200 in your vein, muscle, or with an insulin pump. Also be sure not to:

mix Lyumjev with other insulins or liquids
drive or use heavy machinery until you know how your Lyumjev or Humalog affects you.
drink alcohol or use other medicines that contain alcohol when taking your Lyumjev or Humalog.

Learn more

Lyumjev and Humalog are prescription medicines. For more information, call 1-800-545-5979.

This summary provides basic information about Lyumjev and Humalog. It does not include all information known about these medicines. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other healthcare provider about your insulin lispro product and how to take it. Your doctor is the best person to help you decide if these medicines are right for you.

UR HI CON BS 14OCT2022

Lyumjev^® and Humalog^® are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

INDICATION

LYUMJEV^® (LOOM-jehv) and Humalog^® (HU-ma-log)

Lyumjev is a fast-acting insulin used to control high blood sugar in adults and children with diabetes. Humalog is a fast-acting insulin. Humalog is used to control high blood sugar in adults and children with diabetes.
Lyumjev comes in two strengths: U-100 (100 units per milliliter) and U-200 (200 units per milliliter). Lyumjev U-200 contains 2 times as much insulin in 1 milliliter as Lyumjev U-100. Humalog U-100 contains 100 units of insulin per milliliter. The dose window of the pen shows the number of insulin units to be delivered.
It is not known if Humalog is safe and effective for children with type 2 diabetes or for children younger than 3 years of age with type 1 diabetes as there were no studies done with Humalog in these groups of children. If your doctor decides to give your child any insulin products, he or she may give you special instructions.

All Lyumjev and Humalog products contain insulin lispro.