Lyumjev is a fast-acting insulin used to treat adults with diabetes for the control of high blood sugar
Take Lyumjev with your first bite
Lyumjev starts working fast. Take it at the start of your meal or within 20 minutes after you start eating to reduce your blood sugar.
Select Safety Information
Lyumjev may cause serious side effects. Some of these can lead to death. The possible serious side effects are:
- Low blood sugar. This can cause:
- dizziness or lightheadedness
- blurred vision
- fast heartbeat
- mood change
- slurred speech
If you are at risk of having severely low blood sugar, your doctor may prescribe a glucagon emergency kit. These are used when your blood sugar becomes too low and you are unable to take sugar by mouth. Glucagon helps your body release sugar into your bloodstream.
Lyumjev dosing information
Lyumjev can be taken with a prefilled KwikPen® or from a vial with a syringe, just like Humalog® (insulin lispro). The steps to inject Lyumjev are also the same as for Humalog.
Be sure to take your insulin and check your blood sugar levels exactly as your doctor tells you to. Your doctor may tell you to change your dose because of illness, increased stress, or changes in your weight, diet, or physical activity level. He or she may also tell you to change the amount or time of your dose because of other medicines or different types of insulin you take.
The most common side effects of Lyumjev are:
- Low blood sugar
- Allergic reactions
- Reactions where you have injected insulin
- Thickening or pits at the injection site
- Weight gain
In clinical studies, up to 3% of people taking Lyumjev experienced injection site reactions.* These reactions were usually mild.
When taking Lyumjev, it’s important to remember:
- Change (rotate) where you inject your insulin with each dose. This can reduce your chance of getting pits, lumps, or thickened skin where you inject your insulin
- Do not inject your insulin into the exact same spot or where the skin has pits or lumps
- Avoid injecting into thickened, tender, bruised, scaly, hard, scarred, or damaged skin
These are not all of the possible side effects. Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch .
Preparing your Pen
- Wash your hands with soap and water.
- Check the Pen to make sure you are taking the right type of insulin. This is especially important if you use more than 1 type of insulin.
- Do not use your Pen past the expiration date printed on the label or for more than 28 days after you first start using the Pen.
- Always use a new needle for each injection to help prevent infections and blocked needles.
Priming your Pen
Prime before each injection.
- Priming your Pen means removing the air from the needle and cartridge that may collect during normal use and ensures that your Pen is working correctly.
- If you do not prime before each injection, you may get too much or too little insulin.
- Continue holding your Pen with the needle pointing up. Push the dose knob in until it stops and “0” is seen in the dose window. Hold the dose knob in and count to 5 slowly.
You should see insulin at the tip of the needle.
- If you do not see insulin, repeat priming steps 6 to 8, but not more than 4 times.
- If you still do not see insulin, change the needle and repeat priming steps 6 to 8.
Small air bubbles are normal and will not affect your dose.
Selecting your dose
- You can give from 1 to 60 units in a single injection.
If your dose is more than 60 units, you will need to give more than 1 injection.
- If you need help with dividing up your dose the right way, ask your healthcare provider.
- Use a new needle for each injection and repeat the priming steps.
Turn the dose knob to select the number of units you need to inject. The dose indicator should line up with your dose.
- The Pen dials 1 unit at a time.
- The dose knob clicks as you turn it.
- Do not dial your dose by counting the clicks. You may dial the wrong dose. This may lead to getting too much insulin or not enough insulin.
- The dose can be corrected by turning the dose knob in either direction until the correct dose lines up with the dose indicator.
- The even numbers are printed on the dial. The example shows 12 units in the dose window.
- The odd numbers, after the number 1, are shown as full lines between the numbers. The example shows 25 units in the dose window.
- Always check the number in the dose window to make sure you have dialed the correct dose.
- The Pen will not let you dial more than the number of units left in the Pen.
If you need to inject more than the number of units left in the Pen, you may either:
inject the amount left in your Pen and then use a new Pen to give the rest of your dose,
- get a new Pen and inject the full dose.
- inject the amount left in your Pen and then use a new Pen to give the rest of your dose,
- It is normal to see a small amount of insulin left in the Pen that you cannot inject.
Giving your injection
- Inject your insulin as your healthcare provider has shown you.
- Change (rotate) your injection sites within the area you choose for each dose to reduce your risk of getting lipodystrophy (pits in skin or thickened skin) and localized cutaneous amyloidosis (skin with lumps) at the injection sites.
- Do not use the exact same spot for each injection.
- Do not inject where the skin has pits, is thickened, or has lumps.
- Do not inject where the skin is tender, bruised, scaly or hard, or into scars or damaged skin.
- Do not try to change your dose while injecting.
Pull the needle out of your skin.
- A drop of insulin at the needle tip is normal. It will not affect your dose.
Check the number in the dose window.
- If you see “0” in the dose window, you have received the full amount you dialed.
- If you do not see “0” in the dose window, you did not receive your full dose. Do not redial. Insert the needle into your skin and finish your injection.
- If you still do not think you received the full amount you dialed for your injection, do not start over or repeat that injection. Monitor your blood glucose as instructed by your healthcare provider.
- If you normally need to give 2 injections for your full dose, be sure to give your second injection.
The plunger only moves a little with each injection, and you may not notice that it moves.
If you see blood after you take the needle out of your skin, press the injection site lightly with a piece of gauze or an alcohol swab. Do not rub the area.
After your injection
Other ways to take Lyumjev
There are other ways to take Lyumjev besides using the Lyumjev U-100 KwikPen. The choices currently available are a vial and syringe for Lyumjev U-100 as well as Lyumjev U-200 KwikPen. To decide which is right for you, ask your doctor and discuss your available options.