Teaming up to empower adults with diabetes

Fast-acting mealtime insulin meets real-time glucose insights with Lyumjev®(insulin lispro-aabc) injection and Dexcom G6 Continuous Glucose Monitoring (CGM) System

Lyumjev is a rapid-acting insulin used to treat adults with diabetes for the control of high blood sugar.

Select Safety Information

Do not take Lyumjev if you have:

  • symptoms of low blood sugar (hypoglycemia)
  • an allergy to insulin lispro-aabc or any of the ingredients in Lyumjev.
Lyumjev and Dexcom Devices

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See the difference Lyumjev could make for your patients with the real-time insights provided by Dexcom G6

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Important Facts About LYUMJEV® (LOOM-jehv)

  • Lyumjev is also known as insulin lispro-aabc injection.
  • Lyumjev is a fast-acting insulin. Lyumjev is used to control high blood sugar in adults with diabetes. It is available only with a prescription.
  • Lyumjev comes in two strengths: U-100 (100 units per milliliter) and U-200 (200 units per milliliter). Lyumjev U-200 contains 2 times as much insulin in 1 milliliter as Lyumjev U-100. The dose window on the pens shows the number of units of Lyumjev to be injected.
  • It is not known if Lyumjev is safe and effective for children.

All Lyumjev products contain insulin lispro.


Do not take Lyumjev if you have:

  • symptoms of low blood sugar (hypoglycemia)
  • an allergy to insulin lispro-aabc or any of the ingredients in Lyumjev.

Do not reuse needles or share your insulin injection supplies with other people. This includes your:

  • prefilled pen for use by a single patient
  • cartridges
  • needles
  • syringes

You or the other person can get a serious infection. This can happen even if you change the needle.

Do not change the type of insulin you take or your dose, unless your doctor tells you to. This could cause low or high blood sugar, which could be serious.

Do not use a syringe to remove Lyumjev from your disposable prefilled pen or cartridge. This can cause you to take too much insulin. Taking too much insulin can lead to severe low blood sugar. This may result in seizures or death.

Lyumjev may cause serious side effects. Some of these can lead to death. The possible serious side effects are:

  • Low blood sugar. This can cause:
    • dizziness or lightheadedness
    • headache
    • shakiness
    • irritability
    • sweating
    • blurred vision
    • fast heartbeat
    • mood change
    • confusion
    • slurred speech
    • anxiety
    • hunger

    If you are at risk of having severely low blood sugar, your doctor may prescribe a glucagon emergency kit. These are used when your blood sugar becomes too low and you are unable to take sugar by mouth. Glucagon helps your body release sugar into your bloodstream.

  • Low potassium in your blood. This can lead to severe breathing problems, irregular heartbeat, and death.
  • Severe allergic reaction.

    Get emergency help right away if you have:

    • a rash over your whole body
    • sweating
    • extreme drowsiness
    • swelling of your face, tongue, or throat
    • trouble breathing
    • a faint feeling
    • dizziness
    • a fast heartbeat
    • shortness of breath
    • confusion
  • Heart failure. Taking diabetes pills called thiazolidinediones (thIE-uh-zOH-li-dEEn-dIE-OHns), or “TZDs,” with Lyumjev may cause heart failure in some people. This includes people who do not have any heart failure or heart problems. If you have heart failure, it may get worse if you take TZDs with Lyumjev. Tell your doctor if you have any new symptoms of heart failure, or if they get worse. Some symptoms of heart failure include: shortness of breath, swelling of ankles and feet, and sudden weight gain. Your doctor may need to change or stop treatment with TZDs and Lyumjev.
  • Sudden onset of high blood sugar and high amounts of ketones in your blood or urine. You can have these serious side effects when your insulin pump or infusion set is not working the right way or if there are handling errors. For these reasons, you may not get the right amount of insulin, so always keep extra insulin and injection supplies with you.

Common side effects

The most common side effects of Lyumjev are:

  • low blood sugar
  • allergic reactions
  • rash
  • reactions or pain at the injection site or infusion site with insulin pump use
  • itching
  • skin thickening or pits at the injection or infusion site
  • weight gain

These are not all of the possible side effects. Tell your doctor if you have any side effects. You can report side effects at 1‑800‑FDA‑1088 or .

Before using

Talk with your doctor about low blood sugar and how to manage it. Also tell your doctor:

  • about all of the medicines you take, including over-the-counter medicines, vitamins, and herbal supplements.
  • about any other prescription medicines you take, especially ones called TZDs.
  • about all of your medical conditions, including if you have heart failure or other heart, liver, or kidney problems.
  • if you are pregnant, breastfeeding, or plan to become pregnant or breastfeed.

How to take

Read the Instructions for Use that come with your Lyumjev. Be sure to take your Lyumjev and check your blood sugar levels exactly as your doctor tells you to. Your doctor may tell you to change your dose because of illness, increased stress, or changes in your weight, diet, or physical activity level. He or she may also tell you to change the amount or time of your dose because of other medicines or different types of insulin you take.

Before injecting your Lyumjev

You can inject your insulin dose yourself, or you can have a trained caregiver inject it for you. Make sure you or your caregiver:

  • Check the insulin label before each injection. This will help you make sure that you are taking the correct insulin.
  • Use a new needle for each injection. You can get a serious infection or the wrong dose of insulin if you reuse needles.
  • Change (rotate) where you inject your insulin with each dose. This can reduce your chance of getting pits, lumps, or thickened skin where you inject your insulin. Do not inject your insulin into the exact same spot or where the skin has pits or lumps. Avoid injecting into thickened, tender, bruised, scaly, hard, scarred, or damaged skin.

When you are ready to inject

  • Inject Lyumjev under your skin at the beginning of a meal or within 20 minutes after you start eating a meal.

Staying safe while taking your Lyumjev

To stay safe while taking your insulin, be sure to never inject Lyumjev U-200 in your vein or with an insulin pump. Also be sure not to:

  • mix Lyumjev with other insulins or liquids
  • drive or use heavy machinery until you know how your Lyumjev affects you.
  • drink alcohol or use other medicines that contain alcohol when taking your Lyumjev.

Learn more

For more information, call 1-800-545-5979 or go to
For more information on Dexcom go to

This summary provides basic information about Lyumjev. It does not include all information known about these medicines. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other healthcare provider about your Lyumjev product and how to take it. Your doctor is the best person to help you decide if these medicines are right for you.

Lyumjev® is a registered trademark owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.